ADX47273 - CAS# 851881-60-2 0127 WS3 was used at 0

WS3 was used at 0

Smiles: CN(C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C(=O)C1=CC=CS1)C(C)=O

alkaline phosphatase (ALP)

IOX4 was used at 10-50 µM final concentration in vitro and in cellular assays

ADX47273 - CAS# 851881-60-2 0127 WS3 was used at 0ADX 47273, CAS No. 851881 60 2, is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC50 = 0. 17 m, with no effect on other mGluR subtypes. In vivo, ADX47273 increased extracellular signal regulated kinase and cAMP responsive element binding protein phosphorylation in hippocampus and prefrontal cortex, both of which are critical for glutamate mediated signal transduction mechanisms. The mGluR (metabotropic glutamate