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E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

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E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCCE2012 is a secretase modulator (GSM). E2012 inhibits 3 hydroxysterol 24 reductase (DHCR24) at the final step in the cholesterol biosynthesis. E2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity. Product information CAS Number: 870843 42 8

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Description

C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

InChiKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N

Hsp90 inhibitor AUY-922 has been shown to bind with high affinity to and inhibit Hsp90

platelet-derived growth factor receptors (PDGFR)

E 2012 - CAS# 870843-42-8 Catalog No.:M10859-2 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCCE2012 is a secretase modulator (GSM). E2012 inhibits 3 hydroxysterol 24 reductase (DHCR24) at the final step in the cholesterol biosynthesis. E2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity. Product information CAS Number: 870843 42 8

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